Smoking level predicts bladder cancer outcome

Posted By: Staff | Jan 17 2013

Smoking causes bladder cancer, and people who smoke heavily have greater odds of developing more aggressive and deadly versions of the disease.  The study, published in Cancer, also shows that testing for certain bladder cancer markers can predict which cases have the highest risk of being deadly. Researchers have known that smoking is one of the most common causes of bladder cancer, but they’ve wondered whether it also affects how the disease progresses. To investigate, the researchers analyzed bladder tumors and smoking history in 212 multi-ethnic patients recruited through the Los Angeles County Cancer Surveillance Program between 1987 and 1996.
The researchers found that the bladder cancers that developed in individuals who smoked intensely were more likely to be deadly than bladder cancers that developed in those who never smoked, or who smoked less. The study also revealed that changes in particular proteins are often present in bladder cancers that have become deadly.

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